Barely Significant
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Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males.

Sci Rep · 2014 · PMC4092328 · PMID 25012721

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highly significantno p-value reported
The present study showed that serum homocysteine levels in elderly male patients showed a marked and highly significant association with carotid RI.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.