Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups.

Pharmacogenomics J · 2014 · PMC4098013 · PMID 24418963

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hedged sentences

0.0001

closest p · 0.0× alpha

0.0510

boldest claim

The sentences

highly significantp=8.40 × 10 −5actually significant

Combined across all replication groups, the gene-based test for SPATA13-AS1 was highly significant (p=8.40 × 10 −5 ), and the statistical association was even stronger when the discovery set was included in the combined analysis (p=7.38 × 10 −7 ).

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of borderline significancep = 0.051so close (0.05 < p ≤ 0.1)

The gene-based association with SABA response was statistically significant for SPATA13-AS1 (p = 0.011) but was of borderline significance for SULT4A1 (p = 0.051) ( Table 2 ).

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