Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.

Int J Mol Sci · 2014 · PMC4100152 · PMID 24918288

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Whereas no correlation was observed between the activities of NQO1, SULTs or NAT1 and 3-NBA-DNA adduct levels in cytosolic samples from several human donors, highly significant correlations were observed between the activity of NAT2 and 3-NBA-derived DNA adduct formation ( r = 0.73, p < 0.01) [ 48 ].

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