A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects.

Front Genet · 2014 · PMC4104702 · PMID 25101110

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highly significantno p-value reported

First, for a wide range of realistic scenarios, highly significant GRSxE is detected despite the absence of individual genotype GxE evidence at the contributing loci.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.