Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis).

For D159687, the minimum effective dose (MED) in the OR trial was 0.5 mg/kg against the primary endpoint measure of improvement in mean correct percent first reaches in difficult trials, and in which we also saw highly significant and effective reduction in total and barrier reaches during difficult trial performance.

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