Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease.

PLoS One · 2014 · PMC4106886 · PMID 25051175

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an increasing trendno p-value reported

In addition, we found that the cellular histone acetylation is elevated in N2a/APPswe cells, and an increasing trend of H3 acetylation in N2a/APPwt cells, which is consistent with the observation that histones are hyperacetylated in human neuroblastoma SH-SY5Y cells by the Aβ peptide [11] , [12] .

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a slightly increasing trendno p-value reported

We found, however, only a slightly increasing trend in cellular histone H3 acetylation in N2a/APPwt cells compared to control cells without reaching the statistical significance.

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