There was a positive trend for lesion probability to increase as a logistic function of nodal degree in all anatomical subsets (basal ganglia; frontal, parietal, temporal and occipital cortices; Supplementary Fig. 5 ) although this was statistically significant only for frontal regions (22% increase of lesion probability per unit increase in weighted degree; P < 10 −4 , permutation test).
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The hubs of the human connectome are generally implicated in the anatomy of brain disorders.
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