Barely Significant
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Two structurally different dienelactone hydrolases (TfdEI and TfdEII) from Cupriavidus necator JMP134 plasmid pJP4 catalyse cis- and trans-dienelactones with similar efficiency.

PLoS One · 2014 · PMC4108320 · PMID 25054964

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highly significantno p-value reported
Therefore, it will be highly significant to clone, overexpress and purify these enzymes and compare their catalytic activity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.