Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII.

The differences obtained were highly significant as evidenced by the retroviral insertion site in chromosome score (RISC) defined as: (oi − ei) 2 /ei values [oi < ei then RISC score × (−1)]. 15 , 16 For the detection of preferred genomic integration sites a cut-off of (oi − ei) 2 /ei = 3 was set.

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