Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication.

Cells co-transfected with the CHIKV RNA and pathway specific constructs, showed a much reduced level of stimulation compared to cells lacking the CHIKV replicon after IMD stimulation and a highly significant reduction in the level of stimulation after JAK/STAT and Toll stimulation (2.5 fold less JAK/STAT stimulation, 3.4 fold less IMD stimulation and 4.9 fold less Toll pathway stimulation in the presence of CHIKV) ( Fig. 5 A–C control versus CHIKV+ E. coli or CHIKV+ B. subtilis [p = <0.001]).

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