Barely Significant
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B cell receptor signaling-based index as a biomarker for the loss of peripheral immune tolerance in autoreactive B cells in rheumatoid arthritis.

PLoS One · 2014 · PMC4109936 · PMID 25057856

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highly significantp = 0.0002actually significant
Noteworthy, RA-related phosphoprotein profile changes are unique to the CD19 + CD27 − IgD + IgM low/− subset of autoreactive B ND cells: nominal logistic fit demonstrated that RA predictive value of the combined phosphorylation profile of several major BCR signaling proteins and Ca 2+ levels in response to BCR stimulation [2] in B ND cells was highly significant (R 2 = 1.0, p = 0.0002), while in mature naïve CD19 + IgM + B cells this predictive value was substantially less evident (R 2 = 0.505, p = 0.053).

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