MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression.

Strikingly, gene set enrichment analysis of this group uncovered a highly significant enrichment of genes previously identified as targets of 3meH3K27 histone modification or Suz12 either by ChIP-on-chip or ChIP-sequencing (data not shown), indicative of possible regulation of these genes by the PRC2 complex containing Ezh2 as a catalytic histone methyltransferase subunit.

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