A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival.

Genome Med · 2014 · PMC4110671 · PMID 25067956

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closest p · 0.0× alpha

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highly significantP < 1e-10actually significant

On applying a relaxed threshold of FDR <0.3 we observed a total of 2,514 BRCA1 -mutation associated CpGs, of which 1,422 (57%) were hypermethylated (hyperM) and 1,092 (43%) were hypomethylated (hypoM) in women who had a BRCA1 mutation (Figure 1 , Additional file 5 ), representing a highly significant skew towards hypermethylated CpGs (Binomial test P < 1e-10).

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