Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells.

A highly significant drop in cell viability (as measured by decreased cloning efficiency of replated cells) was apparent starting from 5 nM of bleomycin only when electric pulses were co-applied ( P < 0.01 to P < 0.001), as had been previously described in similar studies of other cell lines. 35 , 36 At 100 nM, a slight toxicity of the drug alone was observed, such that we selected 50 nM bleomycin in further experiments.

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