Compared with placebo, the use of spironolactone resulted in highly significant reductions in LV mass and arterial stiffness (pulse wave velocity, augmentation index, and aortic distensibility), and improved myocardial diastolic function and collagen turnover [ 27 ].
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Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) trial-a multi-centre, prospective, randomised, open, blinded end-point, 36-month study of 2,616 patients within primary care with stage 3b chronic kidney disease to compare the efficacy of spironolactone 25 mg once daily in addition to routine care on mortality and cardiovascular outcomes versus routine care alone: study protocol for a randomized controlled trial.
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