Pattern of statin use in southern italian primary care: can prescription databases be used for monitoring long-term adherence to the treatment?

PLoS One · 2014 · PMC4114740 · PMID 25072244

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a positive trendno p-value reported

In particular, between 2003 and 2011, the use of these drugs showed a positive trend in Italy, representing also, in the last year of this period, the drug class with the highest expenditure (16.4 euro per capita) in Italy [3] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.