The ER- HER2+ subtype had much higher cytoplasmic 4ICD expression than the ER+ HER2- subtype (P = 0.0094, which was almost significant under Bonferroni's correction).
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The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer.
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