The significance of clinicopathological aspects of tumor for the detection of liver micrometastasis in patients with colorectal cancer.

Hence early detection of micrometastasis could find the patients who derived more benefits from neoadjuvant therapy.[ 11 ] Currently, immunohistochemistry (IHC) and polymerase chain reaction (PCR) techniques are used for the detection of micrometastasis.[ 12 13 14 15 16 ] These techniques mainly focus on the detection of cytokeratins as specific marker of epithelial cells that have been evaluated in previous studies.[ 17 18 ] Today, there is an increasing trend in the use of neoadjuvant therapy in CRC patients for treatment of occult metastasis.[ 19 20 21 ] Therefore case selection for this purpose seems to be important.

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