Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival.

PLoS Genet · 2014 · PMC4117450 · PMID 25078604

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highly significantno p-value reported

Inspection of the allele distribution in newborn offspring ( Figure 1B ) confirmed the highly significant increase in embryonic lethality ( Figure 1C ) among F2rl1 −/− animals carrying one active allele of matriptase ( F2rl1 −/− ;St14 +/− , 40% pre-natal survival), compared to matriptase wildtype animals ( F2rl1 −/− ;St14 +/+ , 90% pre-natal survival).

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