The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

PLoS One · 2014 · PMC4117641 · PMID 25080104

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of borderline significanceno p-value reported

However, we have taken a parallel approach by including in our analysis not only the genes with genome-wide significance (GWAS “white zone”), but also GWAS results of borderline significance (GWAS “grey zone”) with p-values between <10 −5 .

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