Epigallocatechin-3-gallate induces mesothelioma cell death via H2 O2 -dependent T-type Ca2+ channel opening.

However, the induction of necrosis was strictly dose-dependent, whereas caspase 3 activation was prevalent over necrosis at lower doses, but showed a decreasing trend down to values below controls for higher EGCG doses.

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These experiments confirmed that EGCG induces a significant increase of [Ca 2+ ] i and ROS in REN cells, whereas in contrast in mesothelial cells the variation of [Ca 2+ ] i was barely significant, and the ROS increase was significantly lower than in REN cells (Table 2 ).

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