Perinatal nitric oxide therapy prevents adverse effects of perinatal hypoxia on the adult pulmonary circulation.

Finally, the RV/(LV + S) ratio seemed lower in mice exposed to hypoxia and iNO than in controls or mice with perinatal hypoxia, but the difference was not quite significant between mice born in hypoxia in the presence or absence of iNO ( P = 0.0677, using the Mann-Whitney test), as well as between mice born in hypoxia plus iNO and controls ( P = 0.0967, using the Mann-Whitney test).

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