Limitations of the dorsal skinfold window chamber model in evaluating anti-angiogenic therapy during early phase of angiogenesis.

These results were rather puzzling at first but immunohistochemical analysis revealed a slight but significant reduction in the vessel number (Figure 5 ) as well as a highly significant 4-fold increase in pericyte covered vessels when tumors were treated with the Ang-2 inhibitor (Figure 6 ).

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