Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.

Brain Behav · 2014 · PMC4128029 · PMID 25161814

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

did not achieve significanceP < 0.06so close (0.05 < p ≤ 0.1)

Duloxetine-treated rats exhibited a higher percentage of open arm entries than those receiving propranolol ( q = 3.738, P < 0.05); however, the difference in open-arm entries in duloxetine versus vehicle-related animals did not achieve significance ( q = 2.747, P < 0.06) (Fig. 2 E).

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a positive trendP = 0.07so close (0.05 < p ≤ 0.1)

Although the relationship between these factors was not statistically significant, a positive trend was noted ( r 2 = 0.13, F = 3.441, P = 0.07) (Fig. 9 ).

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