Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA.

Interestingly, in cell count experiments, we found that the remarkable reduction of cell proliferation rate induced by metformin in non-differentiated control cells, was greatly reduced in differentiated SKNBE cells exposed to metformin, resulting in a highly significant statistical difference comparing the two experimental groups (Figure 3 B).

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