None of cytokeratins 8, 9, or 18 were downregulated in the MCF10A CDH1 -/- cells (Table 2 ), and as mentioned above, there was a notable trend for tight junction genes such as CLDN1, OCLN, TJP3, and CGN to be upregulated rather than downregulated (Table 1 ).
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E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
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