Loeys-Dietz syndrome: a primer for diagnosis and management.

Genet Med · 2014 · PMC4131122 · PMID 24577266

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may be significantno p-value reported

There may be significant emotional burden related to medical appointments and surgical interventions, the natural history of the disease in the extended family, feelings of isolation or unfairness, and/or fear of the future, both for the affected individual and other family members.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.