Barely Significant
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The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.

J Biol Rhythms · 2014 · PMC4131702 · PMID 24682205

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highly significantp < 0.001actually significant
Comparison by 2-way ANOVA of circadian periods in PER1 and PER2 single-mutant mice, with and without Tau ( Per1- null n = 14, 13; Per2- null n = 10, 12), revealed a highly significant effect of Tau (F 1,80 = 1909, p < 0.001) but not of Per genotype (F 2,80 = 0.099, p = 0.91).

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