Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.

In cells treated with 2,500 or 4,000 μM concentrations of compound 7, significant (p < 0.05) Class 1 (42% for 4,000 μM) and highly significant (p < 0.01) Class 2 (11% and 14% for 2,500 and 4,000 μM, respectively) of damage were observed, with some of the cells displaying Class 3 (12%) DNA damage.

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