Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.

For example, we found highly significant functional enrichment among the interacting partners for the GO terms “cytoskeleton” (P value = 6.6 × 10 −13 ), “TFIID complex” (P value = 1 × 10 −14 ), and “proteasome” (P value = 6.6 × 10 −13 ) ( Haarer et al. 2011 ).

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