borderline significantP < 0.1
For three of the seven SNPs, the between-study heterogeneity Q test P -value was borderline significant (0.01 < P < 0.1) when considering that nine independent tests were conducted; however, the results from the random-effects model allowing for heterogeneity showed negligible difference from those obtained using fixed-effect meta-analysis, and they reached genome-wide significance under both models, demonstrating the lack of evidence for significant heterogeneity of signals between studies (Table II ).