Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.

Br J Cancer · 2014 · PMC4134492 · PMID 24921920

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

of borderline significanceP =0.052so close (0.05 < p ≤ 0.1)

In contrast, RG7388 at 1 and 2 μ M did not significantly reduce the GI 50 of vincristine in the same cells; however, 5 μ M RG7388 did potentiate vincristine activity by 13.3-fold, which was of borderline significance ( P =0.052, paired t -test, Figure 3C and Table 2 ).

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borderline significantno p-value reported

However, when RG7388 was used at the highest tested concentration of 5 μ M with vincristine, a borderline significant 13-fold sensitisation was observed.

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