Further truncation to a 215-bp construct, which excluded the proximal NF-κB1 site but retained the proximal IRF-A, IRF-B, and a cyclic adenosine monophosphate response element (cAMP response element) site, significantly ( P <0.05) reduced HRV-16-induced promoter drive when analyzed as fold induction, but failed to achieve significance when expressed in RLUs.
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Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity.
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