Are pharmaceuticals with evolutionary conserved molecular drug targets more potent to cause toxic effects in non-target organisms?

PLoS One · 2014 · PMC4139295 · PMID 25140792

Europe PMC DOI

hedged sentence

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

not quite significantp>0.066so close (0.05 < p ≤ 0.1)

Additionally, in the latter treatment, there was more than a two-fold decrease in vitellogenin expression (t 4 = 6.763, p<0.0025), whereas this effect in promethazine was positive, although not quite significant (t 4 = 2.511, p>0.066).

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