Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis.

The past 5–10 years have seen an increasing trend for the substitution of conventional 5-FU with oral prodrugs of 5-FU, including capecitabine and S-1. 7 , 16 , 17 S-1, as a single agent, is active for the treatment of gastric, colorectal, head and neck, breast, and pancreatic cancers. 8 , 9 , 18 , 19 The current study is the first report evaluating the safety and efficacy of S-1 chemotherapy in recurrent and metastatic NPC patients after failure of platinum-based chemotherapy.

also in 63,971 other papers