Adipocyte hypertrophy, inflammation and fibrosis characterize subcutaneous adipose tissue of healthy, non-obese subjects predisposed to type 2 diabetes.

PLoS One · 2014 · PMC4141784 · PMID 25148116

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In addition, Tumor Necrosis Factor alpha (TNFA) was highly up-regulated in adipose tissue of FDRs, as was the expression of two markers of macrophage infiltration, CD68 and monocyte chemotactic protein-1 (MCP1/CCL2), which was doubled and highly significant ( Table 4 ).

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