Use of admixture and association for detection of quantitative trait loci in the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples (T2D-GENES) study.

Although the model suggests that for entirely European local ancestry at this region, DBP is expected to be lower compared with other local ancestries, a minor allele at the marker seems to have a positive effect in such a case, with DBP expected to increase by 13% per minor allele carried at the SNP ( e 0.123 ≈1.13), and is also highly significant, with a p-value of 9 × 10 -5 .

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Interestingly, although marginally nonsignificant with a p-value of 0.064, given a Native American local ancestry at the region, the minor allele has a negative effect for the trait (DBP is estimated to be 7% lower per minor allele carried at the marker with e -0.069 ≈0.93).

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