Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.

By using a caspase-3/7 activity assay, we tested the effect of combining mdivi-1 with a series of clinically highly significant drugs with disparate actions, and found that cisplatin is a unique agent whose effect can be greatly enhanced by mdivi-1 (Fig. 1 ).

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