Impact of single nucleotide polymorphism in IL-4, IL-4R genes and systemic concentration of IL-4 on the incidence of glioma in Iraqi patients.

Int J Med Sci · 2014 · PMC4147641 · PMID 25170298

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

very close to significancep=0.053so close (0.05 < p ≤ 0.1)

Although it appears that the T allele in CT and TT genotypes is associated with a protective effect against glioma, the association is insignificant for the CT genotype (OR=0.696, 95%CI=0.287-1.688, p=0.423), but very close to significance (p=0.053) for the TT genotype (OR=0.19, 95%CI=0.035-1.02).

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highly significantno p-value reported

Similarly, the heterozygous (CT) and homozygous mutant (CC) of the SNP S503P of the IL-4R gene demonstrated a significant association with glioma development (OR=0.405, 95% CI=0.17-0.969 and OR=0.147, 95% CI=0.036-0.6 respectively), while the C allele exhibited a highly significant association with protection from glioma formation.

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