ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

A highly significant positive correlation ( R = 0.43, P < 1 × 10 −6 ) between CHK1 and ZEB1 was observed in these breast carcinomas, in which 69% (89 of 129) of the tumors with high ZEB1 expression exhibited high CHK1 expression, and 77% (47 of 61) of the tumors with low ZEB1 expression showed low CHK1 expression ( Fig. 8b ).

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