Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital.

PTEN-dependent abnormalities of signaling are very frequent in GBM, with mutation occurring in between 5% and 40% of all GBM cases, and LOH in 60-80% of all cases.[ 3 12 14 ] Evaluation of cellular PTEN levels through expression profiling platform as well by immunohistochemistry have been found to be of prognostic significance in several other studies.[ 14 ] Srividya et al .[ 12 ] observed that the homozygous PTEN deletion is a highly significant prognostic marker for poor clinical outcome in newly diagnosed cases of GBM.

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