A nonsignificant trend toward an increase was observed with AP infusions during the reversal learning task, suggesting that the blockade of NMDARs in the DMStr mildly impaired intradimensional strategy-shifting ability without disrupting extradimentional strategy-switching.
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N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility.
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