Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.

PLoS Genet · 2014 · PMC4161310 · PMID 25211013

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highly significantno p-value reported

However, similar to the primate analysis, PAML NSsites found a small proportion of sites with a high average dN/dS (∼3%, dN/dS >12), as well as a highly significant gene-wide signature of positive selection ( Figure 4A ; M8 vs.

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