Strong epistatic selection on the RNA secondary structure of HIV.

PLoS Pathog · 2014 · PMC4161434 · PMID 25210786

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highly significantp <2.20×10 −16actually significant

Thus, because there are three possible replacement nucleotides per site, WC sites are ∼66% saturated and nWC sites are ∼90% saturated, and this difference is highly significant ( p <2.20×10 −16 , Binomial test; see Materials and Methods for details).

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