Following 5mC-seq analysis of each of these siKDs, we observed that CBX4 depletion caused an overall trend toward hypermethylation throughout the genome (Fig. 3A ,i, blue arrows), which was readily apparent across gene bodies (Fig. 3B ).
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Following 5mC-seq analysis of each of these siKDs, we observed that CBX4 depletion caused an overall trend toward hypermethylation throughout the genome (Fig. 3A ,i, blue arrows), which was readily apparent across gene bodies (Fig. 3B ).