Linear polynomial equation was selected, showing each term was highly significant toward the viscosity as shown here, CCRD : Y 1 = 44.12 − 3.16 X 1 − 9.03 X 2 − 13.35 X 3 (6) BBD : Y 1 = 44.73 − 2.75 X 1 − 8.41 X 2 − 13.76 X 3 (7) The linear term of sonication time ( P <0.0001) stood out from the rest of the terms, showing the highest F -value followed by sonication amplitude ( P <0.0001) and homogenization rate ( P <0.05).
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Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene.
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