The activity of ERK still showed an increasing trend in KLM1-R when treated with U0126 ( Fig. 5 B), indicating a tolerance to U0126 in KLM1-R compared to KLM1 cells.
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Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer.
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