Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function.

Protein identification using matrix-assisted laser desorption/ionization-time of flight/time of flight mass spectrometry revealed a highly significant score for the glutamyl-prolyl tRNA synthetase (EPRS), an enzyme that controls transcript-specific mRNA and protein synthesis, particularly of inflammatory proteins and downstream effectors of the amino-acid stress pathway. 36 The preferential binding interaction EPRS with iPep624 over control peptide was validated by immunoprecipitation and immunoblotting ( Figure 6b ).

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