Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.

Linear regression of MRI parameters with clinical scores GLM using backward, stepwise regression revealed a highly significant association, confirmed by cross-validation results, between multicontrast MRI features and four clinical scores (Table 1 ): Cortical lesions count and volume, T1, T2, and T2* mean z-score of lesions, T1, T2*, and MTR mean of temporal NAWM together with gender predicted the Symbol Digit Modalities Test (attention function) score (adjusted R2: 0.6, P = 0.0005).

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