Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Mol Syst Biol · 2014 · PMC4188041 · PMID 24803665

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highly significantno p-value reported

We considered FoldX predicted energy changes (ΔΔG values) larger than 1.6 kcal/mol as highly significant (99% confidence interval), as they correspond to twice the standard deviation of the error in FoldX (Kiel et al , 2004 ; Schymkowitz et al , 2005 ; Rakoczy et al , 2011 ).

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